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How does keratolytic agents treat acne?

keratolytic

How does keratolytic agents treat acne?

Keratolytic agents are thought to function by relaxing the cohesiveness of the stratum corneum layer, which serves as a crucial, life sustaining barrier, keeping hydration “in” and harmful foreign agents “out.”

The mechanism of action does not involve keratin lysis as the name implies, but rather disintegration of desmosomes and corneodesmosomes that link keratinocytes of the follicle and bind them to the extracellular matrix, respectively. In this manner, these agents can secondly modulate and correct abnormal follicular keratinization.

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